Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo.
نویسندگان
چکیده
The anthrax toxin protective antigen precursor is activated by proteolytic cleavage by furin or a furin-like protease. We present here data demonstrating that the small stable furin inhibitor hexa-D-arginine amide delays anthrax toxin-induced toxemia both in cells and in live animals, suggesting that furin inhibition may represent a reasonable avenue for therapeutic intervention in anthrax.
منابع مشابه
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ورودعنوان ژورنال:
- Infection and immunity
دوره 72 1 شماره
صفحات -
تاریخ انتشار 2004